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Triple X syndrome, also called trisomy X or 47,XXX, is characterized by the presence of an additional X chromosome in each of a female's cells. Although females with this condition may be taller than average, this chromosomal change typically causes no unusual physical features.

Most females with triple X syndrome have normal sexual development and are able to conceive children. Triple X syndrome is associated with an increased risk of learning disabilities and delayed development of speech and language skills. Delayed development of motor skills such as sitting and walkingweak muscle tone hypotoniaand behavioral and emotional difficulties are also possible, but these characteristics vary widely among affected girls and women.

Seizures or kidney abnormalities occur in about 10 percent of affected females.

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This condition occurs in about 1 in 1, newborn girls. Five to 10 girls with triple X syndrome are born in the United States each day. People normally have 46 chromosomes in each cell. Two of the 46 chromosomes, known as X and Y, are called sex chromosomes because they help determine whether a person will develop male or female sex characteristics. Triple X syndrome from an extra copy of the X chromosome in each of a female's cells.

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As a result of the extra X chromosome, each cell has a total of 47 chromosomes 47,XXX instead of the usual An extra copy of the X chromosome is associated with tall stature, learning problems, and other features in some girls and women. Some females with triple X syndrome have an extra X chromosome in only some of their cells.

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Most cases of triple X syndrome are not inherited. The chromosomal change usually occurs as a random event during the formation of reproductive cells eggs and sperm. An error in cell division called nondisjunction can result in reproductive cells with an abnormal of chromosomes.

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For example, an egg or sperm cell may gain an extra copy of the X chromosome as a result of nondisjunction. If one of these atypical reproductive cells contributes to the genetic makeup ofthe child will have an extra X chromosome in each of the body's cells. It occurs as a random event during cell division in early embryonic development. Genetics Home Reference has merged with MedlinePlus.

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Learn more. The information on this site should not be used as a substitute for professional medical care or advice.

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Contact a health care provider if you have questions about your health. Triple X syndrome.

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From Genetics Home Reference. Description Triple X syndrome, also called trisomy X or 47,XXX, is characterized by the presence of an additional X chromosome in each of a female's cells. Frequency This condition occurs in about 1 in 1, newborn girls.

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Causes People normally have 46 chromosomes in each cell. Learn more about the chromosome associated with Triple X syndrome x chromosome.

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Inheritance Most cases of triple X syndrome are not inherited. Research Studies from ClinicalTrials.

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Am J Med Genet A. Genetic counseling for sex chromosome abnormalities. Am J Med Genet.

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Fifty-one prenatally diagnosed children and adolescents with sex chromosome abnormalities. Triple X syndrome: a review of the literature. Eur J Hum Genet.

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Epub Jul 1. A review of trisomy X 47,XXX.

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Orphanet J Rare Dis. Expanding the phenotype of Triple X syndrome: A comparison of prenatal versus postnatal diagnosis. Epub Sep Citation on PubMed.

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